Physicochemical and Mechanical Characterization of Hydroxyapatite-Chitosan- PVA Composite Scaffolds Based on Marine Fish Bone Sources

Authors

  • Adissha Ristifara Department of Biomedical Engineering, Faculty of Industrial Technology, Institut Teknologi Sumatera, South Lampung, 35365, Indonesia
  • Rosita Wati Department of Biomedical Engineering, Faculty of Industrial Technology, Institut Teknologi Sumatera, South Lampung, 35365, Indonesia
  • Dwi Susanti Department of Biomedical Engineering, Faculty of Industrial Technology, Institut Teknologi Sumatera, South Lampung, 35365, Indonesia
  • Meita Mahardianti Department of Biomedical Engineering, Faculty of Industrial Technology, Institut Teknologi Sumatera, South Lampung, 35365, Indonesia
  • Marsudi Siburian Department of Biomedical Engineering, Faculty of Industrial Technology, Institut Teknologi Sumatera, South Lampung, 35365, Indonesia

DOI:

https://doi.org/10.23960/jemit.489

Keywords:

bone tissue engineering, freeze drying, hydroxyapatite, scaffold bone, chitosan/PVA

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Author Biography

Dwi Susanti, Department of Biomedical Engineering, Faculty of Industrial Technology, Institut Teknologi Sumatera, South Lampung, 35365, Indonesia

Biomedical Engineering Department

References

Aminatun. (2024). Fabrication and biocompatibility evaluation of hydroxyapatite-polycaprolactone-gelatin composite nanofibers as a bone scaffold. RSC Advances, 14(34), 24815-24827. https://doi.org/10.1039/D4RA02485K

Aufan, M. R., Daulay, A. H., Indriani, D., & Nuruddin, A. (2017). Sintesis scaffold alginat-kitosan-karbonat apatit sebagai bone graft menggunakan metode freeze drying. Jurnal Biofisika, 8(1), 16-24.

Azaman, F. A., Zhou, K., Blanes-Martinez, M. D. M., Brennan Fournet, M., & Devine, D. M. (2022). Bioresorbable chitosan-based bone regeneration scaffold using various bioceramics and the alteration of photoinitiator concentration in an extended UV photocrosslinking reaction. Gels, 8(11), Article 696. https://doi.org/10.3390/gels8110696

Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan Republik Indonesia. (2019). Laporan nasional Riskesdas 2018. Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan.

Casimiro, M. H., Pereira, A., Leal, J. P., Rodrigues, G., & Ferreira, L. M. (2021). Chitosan/PVA based membranes processed by gamma radiation as scaffolding materials for skin regeneration. Membranes, 11(8), Article 561. https://doi.org/10.3390/membranes11080561

Chung, J. J., Yoo, J., Sum, B. S. T., Li, S., Lee, S., Kim, T. H., Li, Z., Stevens, M. M., Georgiou, T. K., Jung, Y., & Jones, J. R. (2021). 3D printed porous methacrylate/silica hybrid scaffold for bone substitution. Advanced Healthcare Materials, 10(12), e2100117. https://doi.org/10.1002/adhm.202100117

Cucuruz, A., Ghitulica, C.-D., Voicu, G., Bogdan, C.-A., Dochiu, V., & Popescu, R. C. (2023). Investigation of porous ceramic structures based on hydroxyapatite and wollastonite with potential applications in the field of tissue engineering. Ceramics, 6(4), 2333-2351. https://doi.org/10.3390/ceramics6040143

Davis, R., Patel, M., Smith, J., Kumar, A., & Brown, L. (2022). A comprehensive review on metallic implant biomaterials and their subtractive manufacturing. The International Journal of Advanced Manufacturing Technology, 120(3-4), 1473-1530. https://doi.org/10.1007/s00170-022-08770-8

Devi, L. C., Putra, H. S. D., Kencana, N. B. W., Olatunji, A., & Setiawati, A. (2024). Turning Portunus pelagicus shells into biocompatible scaffolds for bone regeneration. Biomedicines, 12(8), Article 1796. https://doi.org/10.3390/biomedicines12081796

Ghoneum, M., Kenawy, E.-R., Soliman, H. M. A., Abdel-Moaty, M. S., & El-Shanshory, A. A. (2025). Chitosan/Biobran/PVA/chitosan-PVA tri-layered nanofiber scaffold: A biphasic release system with physicochemical properties conducive to skin tissue engineering. Carbohydrate Polymer Technologies and Applications, 11, Article 100878. https://doi.org/10.1016/j.carpta.2025.100878

Hossain, M. S., & Ahmed, S. (2023). FTIR spectrum analysis to predict the crystalline and amorphous phases of hydroxyapatite: A comparison of vibrational motion to reflection. RSC Advances, 13(21), 14625-14630. https://doi.org/10.1039/D3RA02580B

Januariyasa, I. K., Ana, I. D., & Yusuf, Y. (2020). Nanofibrous poly(vinyl alcohol)/chitosan contained carbonated hydroxyapatite nanoparticles scaffold for bone tissue engineering. Materials Science and Engineering: C, 107, Article 110347. https://doi.org/10.1016/j.msec.2019.110347

Kanis, J. A. (2003). Long-term risk of osteoporosis. Osteoporosis International, 11(8), 669-674. https://doi.org/10.1007/s001980070064

Kassapidou, M., Stenport, V. F., Johansson, C. B., Ostberg, A.-K., Hammarstrom Johansson, P., & Hjalmarsson, L. (2021). Inflammatory response to cobalt-chromium alloys fabricated with different techniques. Journal of Oral & Maxillofacial Research, 12(4). https://doi.org/10.5037/jomr.2021.12403

Kementerian Kesehatan Republik Indonesia. (2022, December). Transformasi berhasil turunkan transaksi alat kesehatan impor. https://www.kemkes.go.id

Megat Abdul Wahab, R., Abdullah, N., Zainal Ariffin, S. H., Che Abdullah, C. A., & Yazid, F. (2020). Effects of the sintering process on nacre-derived hydroxyapatite scaffolds for bone engineering. Molecules, 25(14), Article 3129. https://doi.org/10.3390/molecules25143129

Nawafi, M. R., Masruroh, M., & Santjojo, D. J. D. H. (2022). Morphological and mechanical study of gelatin/hydroxyapatite composite-based scaffolds for bone tissue regeneration. Indonesian Journal of Applied Physics, 12(2), Article 235. https://doi.org/10.13057/ijap.v12i2.59365

Panda, M., Joshi, S., Annalakshmi, O., & Venkatraman, B. (2025). Optically stimulated luminescence properties of chicken eggshell derived hydroxyapatite for dosimetry applications. Journal of Radioanalytical and Nuclear Chemistry, 334(1), 807-816. https://doi.org/10.1007/s10967-024-09806-x

Pham Viet Nam, V. H., Nguyen, V. H., & Trung, T. S. (2019). Properties of hydroxyapatites prepared from different fish bones: A comparative study. Ceramics International, 45(16), 20141-20147. https://doi.org/10.1016/j.ceramint.2019.06.280

Pineda-Castillo, S., Bernal-Ballen, A., Bernal-Lopez, C., Segura-Puello, H., Nieto-Mosquera, D., Villamil-Ballesteros, A., Munoz-Forero, D., & Munster, L. (2018). Synthesis and characterization of poly(vinyl alcohol)-chitosan-hydroxyapatite scaffolds: A promising alternative for bone tissue regeneration. Molecules, 23(10), 2414. https://doi.org/10.3390/molecules23102414

Prastyo, A., Ibrahim, F., Hadi, A. E., Febrina, R., Winarno, R., Ermasari, A., & Wahyudi, R. (2023). Review on titanium-based alloys as biomaterials for implant applications. Jurnal Rekayasa, Teknologi, dan Sains, 7(1), 1-58. https://doi.org/10.33024/jrets.v7i1.8762

Purba, R. A. P., Restianingsih, T., Anggraini, R. M., Fendriani, Y., & Deswardani, F. (2024). Ekstraksi dan karakterisasi hidroksiapatit (HAp) dari tulang ikan tenggiri (Scomberomorus commersoni) dengan metode heat treatment. Jurnal Fisika Unand, 13(2), 247-253. https://doi.org/10.25077/jfu.13.2.247-253.2024

Rahmatina, S. P., & Kumala, E. L. C. (2021). Perbedaan jumlah pembuluh darah pada proses penyembuhan tulang tikus Wistar dengan implantasi toothgraft mikrohidroksiapatit dan nanohidroksiapatit [Sarjana thesis, Universitas Brawijaya].

Rahmiati, D. U., Gunanti, G., & Harlina, E. (2021). Evaluasi radiografi terhadap kepadatan tulang hasil implan scaffold 3D bifasik kalsium fosfat alginat pada domba lokal (Ovis aries). Jurnal Veteriner, 22(2), 285-291. https://doi.org/10.19087/jveteriner.2021.22.2.285

Rohania, M., Deswardani, F., Fendriani, Y., Anjelina, R., Anggraini, R. M., Maulana, L. Z., & Pujaningsih, F. B. (2025). Scaffold hidroksiapatit (HAp) dari limbah tulang ikan tenggiri (Scomberomorus commerson): Studi variasi PVA terhadap ukuran kristal dan ukuran pori. Jurnal Riset Fisika Indonesia, 5(2), 121-129. https://doi.org/10.33019/jrfi.v5i2.6410

Rohmadi, R., Harwijayanti, W., Ubaidillah, U., Triyono, J., Diharjo, K., & Utomo, P. (2021). In vitro degradation and cytotoxicity of eggshell-based hydroxyapatite: A systematic review and meta-analysis. Polymers, 13(19), Article 3223. https://doi.org/10.3390/polym13193223

Rossa, H. (2021). Media pembelajaran sistem rangka manusia dengan augmented reality untuk siswa SMP. Media Elektro, 14(1), 11. https://doi.org/10.26714/me.v14i1.6026

Sembiring, T. E., & Rahmadhany, H. (2022). Karakteristik penderita fraktur femur akibat kecelakaan lalu lintas di RSUP Haji Adam Malik Medan pada tahun 2016-2018. Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara, 21(1), 123-128. https://doi.org/10.30743/ibnusina.v21i1.244

Tekin, Y. S., & Ates, T. (2024). Comprehensive investigation of the electronic properties of zinc and cobalt doped hydroxyapatite. Journal of the Australian Ceramic Society, 60(4), 1219-1231. https://doi.org/10.1007/s41779-024-01024-8

Yanti, P. H., & Gandi, Y. (2020). Pengaruh waktu kalsinasi terhadap sifat fisika-kimia hidroksiapatit dari cangkang Geloina coaxans. Chemistry Progress, 13(2). https://doi.org/10.35799/cp.13.2.2020.31473

Yazdanpanah, Z., Sharma, N. K., Raquin, A., Cooper, D. M. L., Chen, X., & Johnston, J. D. (2023). Printing tissue-engineered scaffolds made of polycaprolactone and nano-hydroxyapatite with mechanical properties appropriate for trabecular bone substitutes. BioMedical Engineering OnLine, 22(1), Article 73. https://doi.org/10.1186/s12938-023-01135-6

Zhu, Q., Ablikim, Z., Chen, T., Cai, Q., Xia, J., Jiang, D., & Wang, S. (2017). The preparation and characterization of HA/beta-TCP biphasic ceramics from fish bones. Ceramics International, 43(15), 12213-12220. https://doi.org/10.1016/j.ceramint.2017.06.082

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Published

2026-08-31

How to Cite

Ristifara, A., Wati, R., Susanti, D., Mahardianti, M., & Siburian, M. (2026). Physicochemical and Mechanical Characterization of Hydroxyapatite-Chitosan- PVA Composite Scaffolds Based on Marine Fish Bone Sources. Journal of Energy, Material, and Instrumentation Technology, 7(3), 165–176. https://doi.org/10.23960/jemit.489