Monte Carlo Simulation of Dose Distribution in Prostate Cancer of Boron Neutron Capture Therapy (BNCT) Using PHITS v.3.35

Muhammad Nashrun Basyaruddin; Raditya Faradina  Pratiwi; Yohannes  Sardjono; Gede Sutrisna  Wijaya; Isman Mulyadi  Triatmoko; Fendinugroho; Nunung  Nuraeni; Heru  Prasetio

doi:10.23960/jemit.406

Authors

Muhammad Nashrun Basyaruddin Department of Physics, Faculty of Mathematics and Natural Sciences, Defense University, IPSC Sentul Bogor
Raditya Faradina Pratiwi Department of Physics, Faculty of Mathematics and Natural Sciences, Defense University, IPSC Sentul Bogor
Yohannes Sardjono Research Center for Safety, Meteorology and Nuclear Quality Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency
Gede Sutrisna Wijaya Research Center for Safety, Meteorology and Nuclear Quality Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency
Isman Mulyadi Triatmoko Research Center for Safety, Meteorology and Nuclear Quality Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency
Fendinugroho Research Center for Safety, Meteorology and Nuclear Quality Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency
Nunung Nuraeni Research Center for Safety, Meteorology and Nuclear Quality Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency
Heru Prasetio Research Center for Safety, Meteorology and Nuclear Quality Technology, Research Organization for Nuclear Energy, National Research and Innovation Agency

DOI:

https://doi.org/10.23960/jemit.406

Keywords:

BNCT,Prostate Cancer , PHITS, Monte Carlo Simulation, Dosimetry

Abstract

Prostate cancer is the fifth leading cause of cancer death in men worldwide. With its ability to selectively kill tumor cells, Boron Neutron Capture Therapy (BNCT) has reemerged as a promising radiation therapy option for treating prostate cancer. This therapy is known for delivering high doses directly to the target while minimizing damage to healthy tissue. This study aims to analyze the absorbed dose and irradiation time in prostate cancer BNCT under different beam angles using the Particle and Heavy Ion Transport code System (PHITS) v3.35. A computational phantom based on the ORNL adult male model was constructed, incorporating a prostate tumor with a diameter of 1.277 cm to represent a localized lesion. The neutron source was modeled as a 30 MeV proton accelerator and boron concentrations of 84, 104, and 124 ug/g were applied to evaluate their influence on total dose rate and treatment duration at irradiation angles of 0 deg, 30 deg, and 60 deg. Results indicate that higher boron concentration significantly reduces irradiation time while maintaining organ-at-risk (OAR) doses below 5 Gy. The optimal configuration was achieved at 0 deg with a boron concentration of 124 ug/g, resulting in a total irradiation time of 30.59 minutes and a tumor equivalent dose of ~76 Gy. These findings confirm the feasibility of PHITS-based Monte Carlo modeling for optimizing BNCT treatment planning in prostate cancer.

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